Differentially expressed microRNAs revealed by molecular signatures of Preeclampsia and IUGR in human placenta - GSE35574
The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n=94) set of human placentas in order to uncover gene expression patterns (or molecular signatures) associated with preeclampsia and IUGR. Besides modulated modularity clustering and pathway analysis, a set of candidate miRNAs were predicted by Gene Set Enrichment Analysis (GSEA) based on differentially expressed genes. A case-control study was conducted to examine the expression patterns of these candidate miRNAs in human placentas
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| 35 IUGR (including 8 technical repeats for batch effect), 19 preeclamptic and 40 control placentas included in this study were collected during the years of 2004-2008 and hybridized in two batches to microarrays. Samples were randomized across arrays to control for array and batch variability. |
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| Sample ID | !Sample_title | tissue | gestational age | gender | batch |
|---|---|---|---|---|---|
| GSM871046 | Human.Placenta.003 | placenta | 38 | m | A |
| GSM871047 | Human.Placenta.006 | placenta | 36 | f | A |
| GSM871048 | Human.Placenta.008 | placenta | 37 | f | A |
| GSM871049 | Human.Placenta.012 | placenta | 37 | m | A |
| GSM871050 | Human.Placenta.013 | placenta | 34 | m | A |
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| Sample ID | !Sample Title | Tissue | Gestational age | Gender | Batch | Classification | Induction of labor |
|---|---|---|---|---|---|---|---|
| GSM871046 | Human.Placenta.003 |
placenta |
38 |
m |
A |
IUGR |
spontaneous |
| GSM871047 | Human.Placenta.006 |
placenta |
36 |
f |
A |
PE |
spontaneous |
| GSM871048 | Human.Placenta.008 |
placenta |
37 |
f |
A |
IUGR |
induced |
| GSM871049 | Human.Placenta.012 |
placenta |
37 |
m |
A |
PE |
induced |
| GSM871050 | Human.Placenta.013 |
placenta |
34 |
m |
A |
PE |
induced |
| GSM871051 | Human.Placenta.623 |
placenta |
39 |
m |
A |
CONTROL |
spontaneous |
| GSM871052 | Human.Placenta.624 |
placenta |
39 |
m |
A |
CONTROL |
spontaneous |
| GSM871053 | Human.Placenta.654 |
placenta |
37 |
f |
A |
IUGR |
spontaneous |
| GSM871054 | Human.Placenta.657 |
placenta |
39 |
f |
A |
CONTROL |
spontaneous |
| GSM871055 | Human.Placenta.660 |
placenta |
37 |
f |
A |
IUGR |
induced |
| GSM871056 | Human.Placenta.668 |
placenta |
37 |
m |
A |
CONTROL |
spontaneous |
| GSM871057 | Human.Placenta.694 |
placenta |
39 |
f |
A |
IUGR |
spontaneous |
| GSM871058 | Human.Placenta.695 |
placenta |
35 |
m |
A |
CONTROL |
spontaneous |
| GSM871059 | Human.Placenta.701 |
placenta |
37 |
f |
A |
CONTROL |
induced |
| GSM871060 | Human.Placenta.705 |
placenta |
38 |
m |
A |
CONTROL |
spontaneous |
| GSM871061 | Human.Placenta.734 |
placenta |
37 |
m |
A |
IUGR |
induced |
| GSM871062 | Human.Placenta.740 |
placenta |
37 |
f |
A |
IUGR |
spontaneous |
| GSM871063 | Human.Placenta.741 |
placenta |
38 |
f |
A |
IUGR |
spontaneous |
| GSM871064 | Human.Placenta.748 |
placenta |
38 |
m |
A |
CONTROL |
induced |
| GSM871065 | Human.Placenta.757 |
placenta |
37 |
f |
A |
IUGR |
spontaneous |
| GSM871066 | Human.Placenta.777 |
placenta |
38 |
f |
A |
CONTROL |
spontaneous |
| GSM871067 | Human.Placenta.779 |
placenta |
37 |
f |
A |
CONTROL |
spontaneous |
| GSM871068 | Human.Placenta.784 |
placenta |
38 |
f |
A |
CONTROL |
spontaneous |
| GSM871069 | Human.Placenta.654.rep |
placenta |
37 |
f |
B |
IUGR |
spontaneous |
| GSM871070 | Human.Placenta.017 |
placenta |
38 |
m |
B |
PE |
induced |
| GSM871071 | Human.Placenta.703 |
placenta |
37 |
f |
B |
CONTROL |
spontaneous |
| GSM871072 | Human.Placenta.769 |
placenta |
35 |
f |
B |
IUGR |
induced |
| GSM871073 | Human.Placenta.034 |
placenta |
39 |
m |
B |
IUGR |
induced |
| GSM871074 | Human.Placenta.710 |
placenta |
37 |
f |
B |
CONTROL |
spontaneous |
| GSM871075 | Human.Placenta.758 |
placenta |
39 |
m |
B |
CONTROL |
spontaneous |
| GSM871076 | Human.Placenta.037 |
placenta |
27 |
f |
B |
PE |
induced |
| GSM871077 | Human.Placenta.761 |
placenta |
38 |
m |
B |
CONTROL |
spontaneous |
| GSM871078 | Human.Placenta.018 |
placenta |
37 |
f |
B |
IUGR |
induced |
| GSM871079 | Human.Placenta.734.rep |
placenta |
37 |
m |
B |
IUGR |
induced |
| GSM871080 | Human.Placenta.032 |
placenta |
38 |
f |
B |
PE |
spontaneous |
| GSM871081 | Human.Placenta.009 |
placenta |
34 |
m |
B |
PE |
induced |
| GSM871082 | Human.Placenta.653 |
placenta |
37 |
m |
B |
IUGR |
induced |
| GSM871083 | Human.Placenta.646 |
placenta |
39 |
f |
B |
CONTROL |
spontaneous |
| GSM871084 | Human.Placenta.766 |
placenta |
29 |
m |
B |
IUGR |
induced |
| GSM871085 | Human.Placenta.003.rep |
placenta |
38 |
m |
B |
IUGR |
spontaneous |
| GSM871086 | Human.Placenta.726 |
placenta |
37 |
f |
B |
CONTROL |
spontaneous |
| GSM871087 | Human.Placenta.738 |
placenta |
33 |
m |
B |
IUGR |
induced |
| GSM871088 | Human.Placenta.660.rep |
placenta |
37 |
f |
B |
IUGR |
induced |
| GSM871089 | Human.Placenta.730 |
placenta |
38 |
f |
B |
CONTROL |
spontaneous |
| GSM871090 | Human.Placenta.743 |
placenta |
39 |
m |
B |
CONTROL |
induced |
| GSM871091 | Human.Placenta.021 |
placenta |
35 |
f |
B |
PE |
induced |
| GSM871092 | Human.Placenta.011 |
placenta |
32 |
f |
B |
IUGR |
spontaneous |
| GSM871093 | Human.Placenta.744 |
placenta |
37 |
m |
B |
CONTROL |
spontaneous |
| GSM871094 | Human.Placenta.015 |
placenta |
32 |
f |
B |
PE |
induced |
| GSM871095 | Human.Placenta.694.rep |
placenta |
39 |
f |
B |
IUGR |
spontaneous |
| GSM871096 | Human.Placenta.024 |
placenta |
34 |
m |
B |
PE |
induced |
| GSM871097 | Human.Placenta.746 |
placenta |
38 |
m |
B |
CONTROL |
spontaneous |
| GSM871098 | Human.Placenta.740.rep |
placenta |
37 |
f |
B |
IUGR |
spontaneous |
| GSM871099 | Human.Placenta.763 |
placenta |
37 |
m |
B |
CONTROL |
spontaneous |
| GSM871100 | Human.Placenta.036 |
placenta |
36 |
m |
B |
PE |
induced |
| GSM871101 | Human.Placenta.774 |
placenta |
40 |
f |
B |
CONTROL |
induced |
| GSM871102 | Human.Placenta.775 |
placenta |
38 |
m |
B |
CONTROL |
spontaneous |
| GSM871103 | Human.Placenta.022 |
placenta |
37 |
m |
B |
IUGR |
induced |
| GSM871104 | Human.Placenta.776 |
placenta |
39 |
m |
B |
CONTROL |
induced |
| GSM871105 | Human.Placenta.741.rep |
placenta |
38 |
f |
B |
IUGR |
spontaneous |
| GSM871106 | Human.Placenta.735 |
placenta |
26 |
f |
B |
IUGR |
spontaneous |
| GSM871107 | Human.Placenta.041 |
placenta |
37 |
f |
B |
PE |
induced |
| GSM871108 | Human.Placenta.787 |
placenta |
34 |
f |
B |
CONTROL |
spontaneous |
| GSM871109 | Human.Placenta.757.rep |
placenta |
37 |
f |
B |
IUGR |
spontaneous |
| GSM871110 | Human.Placenta.659 |
placenta |
32 |
f |
B |
IUGR |
spontaneous |
| GSM871111 | Human.Placenta.652 |
placenta |
36 |
m |
B |
CONTROL |
spontaneous |
| GSM871112 | Human.Placenta.010 |
placenta |
38 |
f |
B |
PE |
spontaneous |
| GSM871113 | Human.Placenta.678 |
placenta |
37 |
f |
B |
IUGR |
spontaneous |
| GSM871114 | Human.Placenta.662 |
placenta |
39 |
m |
B |
CONTROL |
spontaneous |
| GSM871115 | Human.Placenta.674 |
placenta |
38 |
m |
B |
CONTROL |
spontaneous |
| GSM871116 | Human.Placenta.682 |
placenta |
35 |
f |
B |
CONTROL |
spontaneous |
| GSM871117 | Human.Placenta.014 |
placenta |
29 |
m |
B |
PE |
induced |
| GSM871118 | Human.Placenta.687 |
placenta |
36 |
m |
B |
CONTROL |
spontaneous |
| GSM871119 | Human.Placenta.693 |
placenta |
39 |
m |
B |
CONTROL |
spontaneous |
| GSM871120 | Human.Placenta.767 |
placenta |
28 |
m |
B |
IUGR |
spontaneous |
| GSM871121 | Human.Placenta.698 |
placenta |
37 |
f |
B |
IUGR |
induced |
| GSM871122 | Human.Placenta.020 |
placenta |
28 |
f |
B |
PE |
induced |
| GSM871123 | Human.Placenta.749 |
placenta |
39 |
m |
B |
CONTROL |
induced |
| GSM871124 | Human.Placenta.016 |
placenta |
33 |
m |
B |
IUGR |
induced |
| GSM871125 | Human.Placenta.751 |
placenta |
38 |
f |
B |
CONTROL |
spontaneous |
| GSM871126 | Human.Placenta.031 |
placenta |
32 |
f |
B |
PE |
spontaneous |
| GSM871127 | Human.Placenta.756 |
placenta |
39 |
f |
B |
CONTROL |
spontaneous |
| GSM871128 | Human.Placenta.045 |
placenta |
34 |
m |
B |
PE |
spontaneous |
| GSM871129 | Human.Placenta.038 |
placenta |
37 |
f |
B |
IUGR |
spontaneous |
| GSM871130 | Human.Placenta.798 |
placenta |
38 |
m |
B |
CONTROL |
spontaneous |
| GSM871131 | Human.Placenta.047 |
placenta |
33 |
f |
B |
PE |
induced |
| GSM871132 | Human.Placenta.039 |
placenta |
37 |
m |
B |
IUGR |
induced |
| GSM871133 | Human.Placenta.801 |
placenta |
29 |
m |
B |
CONTROL |
spontaneous |
| GSM871134 | Human.Placenta.617 |
placenta |
40 |
f |
B |
CONTROL |
induced |
| GSM871135 | Human.Placenta.636 |
placenta |
37 |
m |
B |
IUGR |
spontaneous |
| GSM871136 | Human.Placenta.625 |
placenta |
39 |
f |
B |
CONTROL |
spontaneous |
| GSM871137 | Human.Placenta.005 |
placenta |
27 |
f |
B |
PE |
induced |
| GSM871138 | Human.Placenta.626 |
placenta |
38 |
m |
B |
CONTROL |
spontaneous |
| GSM871139 | Human.Placenta.764 |
placenta |
25 |
f |
B |
IUGR |
spontaneous |
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